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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
27/01/2020 |
Actualizado : |
27/01/2020 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
ESCRIBANO, C.; SARAVIA, A.; COSTA, M.; CASTELLS, D.; CIAPPESONI, G.; RIET-CORREA, F.; FREIRE, T. |
Afiliación : |
CECILIA ESCRIBANO, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MONIQUE COSTA, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; DANIEL CASTELLS, Secretariado Uruguayo de Lana, Florida, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
Título : |
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response. |
Fecha de publicación : |
2019 |
Fuente / Imprenta : |
Scientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6 |
ISSN : |
2045-2322 |
DOI : |
10.1038/s41598-019-55447-6 |
Idioma : |
Inglés |
Notas : |
Article history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019.
Funding information:
We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA. |
Contenido : |
ABSTRACT.
Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
© 2019, The Author(s). |
Palabras claves : |
HAEMONCHUS; SHEEP. |
Asunto categoría : |
L01 Ganadería |
URL : |
https://www.nature.com/articles/s41598-019-55447-6.pdf
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Marc : |
LEADER 02635naa a2200253 a 4500 001 1060699 005 2020-01-27 008 2019 bl uuuu u00u1 u #d 022 $a2045-2322 024 7 $a10.1038/s41598-019-55447-6$2DOI 100 1 $aESCRIBANO, C. 245 $aResistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.$h[electronic resource] 260 $c2019 500 $aArticle history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019. Funding information: We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA. 520 $aABSTRACT. Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks. © 2019, The Author(s). 653 $aHAEMONCHUS 653 $aSHEEP 700 1 $aSARAVIA, A. 700 1 $aCOSTA, M. 700 1 $aCASTELLS, D. 700 1 $aCIAPPESONI, G. 700 1 $aRIET-CORREA, F. 700 1 $aFREIRE, T. 773 $tScientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Treinta y Tres. |
Fecha actual : |
07/12/2015 |
Actualizado : |
07/12/2015 |
Tipo de producción científica : |
Actividades de Difusión |
Autor : |
JORNADA PRODUCCIÓN DE CARNE EN ROTACIÓN CON ARROZ, 4, 1979, CIAAB-EEE, TREINTA Y TRES, UY.; GRIERSON, J.; BONILLA, O.; ACEVEDO, A.; CHEBATAROFF, N.; BLANCO, F.; VAZ MARTINS, D. |
Afiliación : |
JOHN ANDREW GRIERSON BRUCE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; OSCAR RUBEN BONILLA PIRIZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANTONIO MARIA ACEVEDO VEGA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; NICOLÁS CHEBATAROFF, Proyecto Arroz, CIAAB.; FEDERICO GUILLERMO BLANCO BORDÓN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DANIEL VAZ MARTINS GIGENA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
IV Jornada producción de carne en rotación con arroz |
Fecha de publicación : |
1979 |
Fuente / Imprenta : |
Treinta y Tres (Uruguay): CIAAB; EEE, 1979 |
Páginas : |
37 p. |
Idioma : |
Español |
Contenido : |
Producción de carne en rotaciones con arroz.
Manejo de suelos arroceros.
Engorde de novillos en praderas cultivadas. |
Palabras claves : |
ROTACIONES ARROZ-PASTURAS. |
Thesagro : |
ARROZ; ENGORDE; NOVILLOS; ROTACIONES CULTIVOS-PASTURAS; SUELOS. |
Asunto categoría : |
F01 Cultivo |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/5358/1/IV-Jornada-Produccion-de-carne-en-rotacion-de-arroz.-1979.pdf
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Marc : |
LEADER 00897nam a2200265 a 4500 001 1054075 005 2015-12-07 008 1979 bl uuuu u00u1 u #d 100 1 $aJORNADA PRODUCCIÓN DE CARNE EN ROTACIÓN CON ARROZ, 4, 1979, CIAAB-EEE, TREINTA Y TRES, UY. 245 $aIV Jornada producción de carne en rotación con arroz$h[electronic resource] 260 $aTreinta y Tres (Uruguay): CIAAB; EEE$c1979 300 $a37 p. 520 $aProducción de carne en rotaciones con arroz. Manejo de suelos arroceros. Engorde de novillos en praderas cultivadas. 650 $aARROZ 650 $aENGORDE 650 $aNOVILLOS 650 $aROTACIONES CULTIVOS-PASTURAS 650 $aSUELOS 653 $aROTACIONES ARROZ-PASTURAS 700 1 $aGRIERSON, J. 700 1 $aBONILLA, O. 700 1 $aACEVEDO, A. 700 1 $aCHEBATAROFF, N. 700 1 $aBLANCO, F. 700 1 $aVAZ MARTINS, D.
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INIA Treinta y Tres (TT) |
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